Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Placzek, F; Micko, A; Sentosa, R; Fonollà, R; Winklehner, M; Hosmann, A; Andreana, M; Höftberger, R; Drexler, W; Leitgeb, RA; Wolfsberger, S; Unterhuber, A.
Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation.
Biomed Opt Express. 2020; 11(12):7003-7018
Doi: 10.1364/BOE.409987
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Web of Science
PubMed
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- Leading authors Med Uni Graz
- Micko Alexander
- Co-authors Med Uni Graz
- Wolfsberger Stefan
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- Abstract:
- Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features-cell groups with reticulin framework-detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.