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Altenberger, T; Bilban, M; Auer, M; Knosp, E; Wolfsberger, S; Gartner, W; Mineva, I; Zielinski, C; Wagner, L; Luger, A.
Identification of DLK1 variants in pituitary- and neuroendocrine tumors.
Biochem Biophys Res Commun. 2006; 340(3):995-1005 Doi: 10.1016/j.bbrc.2005.12.094
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Co-authors Med Uni Graz: Wolfsberger Stefan
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Abstract:: In a gene chip analysis of common pituitary tumor types, one of the genes with the most impressive tissue-specific expression regulation was delta-like 1 (DLK1), which was strongly expressed in GH-secreting (GH-S) pituitary tumors. In addition to pituitary adenomas, various endocrine tumors were subjected to real-time-quantitative PCR revealing high expression of DLK1 in normal pituitary tissue, in GH-S-, in one prolactin-secreting pituitary adenoma and in pheochromocytomas. Additionally, three DLK1 gene-derived subvariants were identified. The first, lacking 204 bp--coding for epidermal growth factor-like domain 6 and parts of the juxtamembrane region--was named Secredeltin. In the other two splice variants (named Brevideltin and Brevideltinin), a stop codon is introduced due to a frame-shift, leading to truncated proteins of 204 and 213 aas, respectively.
Find related publications in this database (using NLM MeSH Indexing): Alternative Splicing - administration & dosage; Base Sequence - administration & dosage; Blotting, Northern - administration & dosage; Calcium-Binding Proteins - administration & dosage; Cloning, Molecular - administration & dosage; Codon, Terminator - administration & dosage; DNA - chemistry, metabolism; DNA, Complementary - metabolism; Female - administration & dosage; Gene Expression Profiling - administration & dosage; Gene Expression Regulation - administration & dosage; Gene Expression Regulation, Neoplastic - administration & dosage; Genetic Variation - administration & dosage; Humans - administration & dosage; Immunoblotting - administration & dosage; Intercellular Signaling Peptides and Proteins - administration & dosage; Male - administration & dosage; Membrane Proteins - biosynthesis, chemistry, metabolism; Microscopy, Confocal - administration & dosage; Microscopy, Fluorescence - administration & dosage; Models, Genetic - administration & dosage; Molecular Sequence Data - administration & dosage; Neuroendocrine Tumors - metabolism; Oligonucleotide Array Sequence Analysis - administration & dosage; Ovarian Neoplasms - metabolism; Pituitary Neoplasms - metabolism; Polymerase Chain Reaction - administration & dosage; Protein Structure, Tertiary - administration & dosage; RNA, Messenger - metabolism; Recombinant Proteins - chemistry; Repressor Proteins - biosynthesis, chemistry, metabolism; Reverse Transcriptase Polymerase Chain Reaction - administration & dosage; Sequence Homology, Nucleic Acid - administration & dosage; Time Factors - administration & dosage
Find related publications in this database (Keywords): DLK1; pref-1; transcript variants; neuroendocrine tumors; pituitary adenomas; pituitary