Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Preusser, M; Wolfsberger, S; Czech, T; Slavc, I; Budka, H; Hainfellner, JA.
Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome.
Am J Clin Pathol. 2005; 124(4):543-9
Doi: 10.1309/PP2G5GAAFKV82DTG
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Wolfsberger Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Survivin expression has been described as prognostic factor in various tumor types and has been shown to correlate with cytologic anaplasia in ependymoma. We immunohistochemically studied survivin expression and its association with Ki-67 and topoisomerase IIalpha (TIIalpha) expression and outcome in 63 patients with intracranial ependymoma. Survivin is expressed in a fraction of nuclei of tumor and endothelial cells including mitotic figures. Survivin indices range from 0.6% to 43.2% and correlate with Ki-67 and TIIalpha indices. On average, 62.86% of Ki-67-expressing tumor cell nuclei coexpress survivin, whereas 92.2% of survivin-expressing nuclei coexpress Ki-67. High survivin, Ki-67, and TIIalpha indices univariately correlated with an unfavorable outcome. In multivariate analysis, only the Ki-67 index remained an independent prognostic factor. In ependymoma, survivin is expressed in a subset of proliferating cells. High survivin expression is associated with poor patient outcome. However, the Ki-67 index is a more accurate prognostic marker than the survivin or TIIalpha index.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Antigens, Neoplasm - metabolism
- Austria - epidemiology
- Biomarkers, Tumor - administration & dosage
- Brain Neoplasms - metabolism, mortality, pathology, surgery
- Cell Nucleus - metabolism, pathology
- Cell Proliferation - administration & dosage
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Cohort Studies - administration & dosage
- Cysteine Proteinase Inhibitors - metabolism
- DNA Topoisomerases, Type II - metabolism
- DNA-Binding Proteins - metabolism
- Ependymoma - metabolism, mortality, secondary, surgery
- Humans - administration & dosage
- Infant - administration & dosage
- Inhibitor of Apoptosis Proteins - administration & dosage
- Ki-67 Antigen - metabolism
- Microtubule-Associated Proteins - metabolism
- Middle Aged - administration & dosage
- Neoplasm Proteins - metabolism
- Neoplasm Staging - administration & dosage
- Prognosis - administration & dosage
- Survival Rate - administration & dosage
- Survivin - administration & dosage
- Find related publications in this database (Keywords)
- apoptosis
- ependymoma
- proliferation
- prognosis
- survivin