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SHR Neuro Cancer Cardio Lipid Metab Microb

Schaefer, C; Zamboglou, C; Volegova-Neher, N; Martini, C; Nicolay, NH; Schmidt-Hegemann, NS; Rogowski, P; Li, M; Belka, C; Müller, AC; Grosu, AL; Brunner, T.
Impact of a low FODMAP diet on the amount of rectal gas and rectal volume during radiotherapy in patients with prostate cancer - a prospective pilot study.
Radiat Oncol. 2020; 15(1):27 Doi: 10.1186/s13014-020-1474-y [OPEN ACCESS]
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Co-authors Med Uni Graz: Brunner Thomas Baptist
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Abstract:: BACKGROUND: Small inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and rectal volume are known to have a relevant effect on prostate motion, this study aims to reduce these parameters by using a Low FODMAP Diet (LFD) and to show feasibility of this intervention. METHODS: We compared a prospective intervention group (IG, n = 25) which underwent RT for PCa and whose patients were asked to follow a LFD during RT with a retrospective control group (CG, n = 25) which did not get any dietary advice. In the planning CT scan and all available cone beam CT scans rectal gas was classified based on a semiquantitative score (scale from 1 to 5) and rectal volume was measured. Furthermore, patients' compliance was evaluated by a self-assessment questionnaire. RESULTS: Clinical and treatment characteristics were well balanced between both groups. A total of 266 (CG, 10.6 per patient) and 280 CT scans (IG, 11.2 per patient), respectively, were analysed. The frequency distribution of gas scores differed significantly from each other (p < .001) with the IG having lower scores. Rectal volume was smaller in the IG (64.28 cm³, 95% CI 60.92-67.65 cm³, SD 28.64 cm³) than in the CG (71.40 cm³, 95% CI 66.47-76.32 cm³, SD 40.80 cm³) (p = .02). Mean intrapatient standard deviation as a measure for the variability of rectal volume was 22 cm³ in the IG and 23 cm³ in the CG (p = .81). Patients' compliance and contentment were satisfying. CONCLUSIONS: The use of a LFD significantly decreased rectal gas and rectal volume. LFD was feasible with an excellent patients' compliance. However, prospective trials with a larger number of patients and a standardized evaluation of gastrointestinal toxicity and quality of life are reasonable. TRIAL REGISTRATION: German Clinical Trials Register, DRKS00012955. Registered 29 August 2017 - Retrospectively registered, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00012955.
Find related publications in this database (using NLM MeSH Indexing): Aged - administration & dosage; Diet, Carbohydrate-Restricted - administration & dosage; Germany - administration & dosage; Humans - administration & dosage; Male - administration & dosage; Middle Aged - administration & dosage; Motion - administration & dosage; Patient Compliance - administration & dosage; Pilot Projects - administration & dosage; Prospective Studies - administration & dosage; Prostate - radiation effects; Prostatic Neoplasms - diet therapy, pathology, radiotherapy; Radiotherapy, Intensity-Modulated - adverse effects; Rectum - diagnostic imaging, pathology, physiopathology, radiation effects; Treatment Outcome - administration & dosage
Find related publications in this database (Keywords): Radiotherapy - prostate Cancer; Low FODMAP diet; Rectal volume; Rectal gas