Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunner, TB; Blanck, O; Lewitzki, V; Abbasi-Senger, N; Momm, F; Riesterer, O; Duma, MN; Wachter, S; Baus, W; Gerum, S; Guckenberger, M; Gkika, E.
Stereotactic body radiotherapy dose and its impact on local control and overall survival of patients for locally advanced intrahepatic and extrahepatic cholangiocarcinoma.
Radiother Oncol. 2019; 132:42-47
Doi: 10.1016/j.radonc.2018.11.015
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- PURPOSE: Non-resectable cholangiocarcinoma (CCC) is a significant therapeutic challenge because of bad prognosis. This study analyzed the outcome after SBRT for intra- and extrahepatic CCC. MATERIAL AND METHODS: Sixty-four patients with 82 CCC lesions from a retrospective multicenter database were analyzed. Available parameters were analyzed for local control (LC), overall survival (OS) and toxicity. RESULTS: Median follow-up time for patients alive was 35 months (range 7-91 months). Median overall survival (OS) time was 15 months; 2-year and 3-year OS rates were 32% and 21%. Median prescribed biological effective radiation dose (BED, α/β = 10) was 67.2 Gy10 (range, 36-115 Gy10; SD: 20 Gy10) in median 8 fractions (range, 3-17; 95% CI: 3-12), median BEDmax was 91 Gy10. BED was the only prognostic factor for LC and OS. Patients receiving BEDmax >91 Gy10 had a median OS of 24 months vs. 13 months for those receiving lower doses (p = 0.008). LC rates at 12 and 24 months were 91% and 80% for BEDmax >91 Gy10 vs. 66% and 39% for lower doses (p = 0.009). Of note, tumor size and PTV were neither predictive nor prognostic for LC and OS. Treatment tolerance was good with 17% of grade 1 gastroduodenitis, 11% of grade 2-3 cholangitis and 4.7% of grade 3 gastrointestinal bleeding. CONCLUSION: This is the largest reported series on SBRT in cholangiocarcinoma. Overall survival and local control were significantly improved after higher doses (BED) and tolerance was excellent.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Bile Duct Neoplasms - mortality, radiotherapy
- Bile Ducts, Intrahepatic - pathology, radiation effects
- Cholangiocarcinoma - mortality, radiotherapy
- Dose-Response Relationship, Radiation - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Prognosis - administration & dosage
- Radiosurgery - methods
- Retrospective Studies - administration & dosage
- Survival Rate - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Cholangiocarcinoma
- Stereotactic body radiotherapy
- Unresectable