Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gkika, E; Bettinger, D; Krafft, L; Schultheiss, M; Neeff, HP; Maruschke, L; Schulenburg, M; Adebahr, S; Kirste, S; Nestle, U; Thimme, R; Grosu, AL; Brunner, TB.
The role of albumin-bilirubin grade and inflammation-based index in patients with hepatocellular carcinoma treated with stereotactic body radiotherapy.
Strahlenther Onkol. 2018; 194(5):403-413
Doi: 10.1007/s00066-017-1256-0
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- PURPOSE: We evaluated the prognostic accuracy of the albumin-bilirubin (ALBI) grade and the inflammation-based index (IBI) in estimating overall survival (OS) and toxicity in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: Forty patients with 47 HCC lesions with a Barcelona Clinic Liver Cancer (BCLC) classification stage B or C were treated with SBRT in 3-12 fractions. The ALBI grade and the IBI were calculated at different time points (baseline, during, at the end of treatment and at follow-up) and compared with the Child-Pugh (CP) score as well as other patient- and treatment-related parameters, concerning OS and toxicity. RESULTS: The median follow-up was 14.3 months for patients alive. The median OS from SBRT was 10 (95% confidence interval 8.3-11.6) months. The local control at 1 year was 79%. A lower IBI during treatment was associated with better OS (p = 0.034) but not CP and ALBI. Higher C‑reactive protein levels as well as higher alpha-fetoprotein concentrations correlated with worse survival (p = 0.001). Both higher ALBI (p = 0.02) and CTP (p = 0.001) at baseline correlated with a higher incidence of acute and late toxicities (CTC ≥2). Neither the mean radiation dose to the liver nor the dose to 700 cc of the liver correlated with the occurrence of toxicities. CONCLUSIONS: In this analysis, a higher ALBI grade as well as a higher CP were predictors of higher incidence of toxicity, whereas a lower IBI during treatment correlated with a better OS. These results should be further evaluated in prospective studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Bilirubin - blood
- C-Reactive Protein - metabolism
- Carcinoma, Hepatocellular - blood, classification, pathology, radiotherapy
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Inflammation Mediators - blood
- Liver Neoplasms - blood, classification, pathology, radiotherapy
- Male - administration & dosage
- Middle Aged - administration & dosage
- Neoplasm Staging - administration & dosage
- Prognosis - administration & dosage
- Radiosurgery - methods
- Serum Albumin - metabolism
- Statistics as Topic - administration & dosage
- Survival Analysis - administration & dosage
- alpha-Fetoproteins - metabolism
- Find related publications in this database (Keywords)
- SBRT
- HCC
- ALBI
- IBI
- Liver function