Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Werner, ER; Fuchs, D; Hausen, A; Jaeger, H; Reibnegger, G; Werner-Felmayer, G; Dierich, MP; Wachter, H.
Tryptophan degradation in patients infected by human immunodeficiency virus.
Biol Chem Hoppe Seyler. 1988; 369(5):337-340
Doi: 10.1515/bchm3.1988.369.1.337
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Tryptophan and kynurenine were measured retrospectively in sera of 11 male patients with advanced human immunodeficiency virus (HIV) infection (Walter Reed stages 4 and 6). Tryptophan levels are significantly reduced to less than 50% in patients with HIV infection and kynurenine levels significantly elevated when compared to sex and age matched controls. The decrease of tryptophan levels might contribute to neurologic symptoms often associated with HIV infection. Since interferon-gamma induces degradation of tryptophan via the kynurenine pathway, the present results may be consistent with enhanced endogenous production of interferon-gamma in advanced HIV infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Adult - blood
- Biopterin - analogs and derivatives
- Humans - analogs and derivatives
- Kynurenine - blood
- Male - blood
- Neopterin - blood
- Reference Values - blood
- Retrospective Studies - blood
- Tryptophan - blood