Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunner, TB; Nestle, U; Grosu, AL; Partridge, M.
SBRT in pancreatic cancer: what is the therapeutic window?
Radiother Oncol. 2015; 114(1):109-16
Doi: 10.1016/j.radonc.2014.10.015
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- PURPOSE/OBJECTIVE: To analyse outcome and toxicity of stereotactic body radiotherapy (SBRT) in pancreatic cancer (PDAC). MATERIAL/METHODS: We systematically reviewed full reports on outcome and toxicity transforming prescription doses to equivalent doses of 2 Gy (EQD2) and biological equivalent doses (BED). Pearson product-moment correlation coefficient, regression analysis and Lyman-Kutcher-Burman modelling were used. RESULTS: Sixteen trials (572 patients) were identified. Local control correlated with dose. Additionally 4 upper gastrointestinal-SBRT trials (149 patients) were included for toxicity analysis. Acute toxicity was mild but late toxicity ⩾G2 was substantial and predominantly gastrointestinal. Late toxicity ⩾G2 and ⩾G3 correlated highly with EQD2/BED after linear (R(2)=0.85 and 0.77, respectively) and Lyman-Kutcher-Burman modelling. Linear regression lines indicated ⩾G2 and ⩾G3 toxicity frequencies of 5% at 65 Gy and 80 Gy EQD2-α/β=3, respectively. A comparison of toxicity with dose constraints for duodenum revealed partly inadequate dose constraints. CONCLUSION: RESULTS from multiple fraction regimens could be successfully interpreted to estimate toxicity according to EQD2/BED prescription doses, and dose constraints for the duodenum were derived, whereas local control appeared to be less dose-dependent. This analysis may be useful to plan clinical trials for SBRT and hypofractionated radiotherapy in pancreatic cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Pancreatic Ductal - radiotherapy, surgery
- Humans - administration & dosage
- Pancreatic Neoplasms - radiotherapy, surgery
- Prospective Studies - administration & dosage
- Radiosurgery - methods
- Radiotherapy Dosage - administration & dosage
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- SBRT
- Pancreatic cancer
- Efficacy
- Toxicity