Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lunardi, S; Muschel, RJ; Brunner, TB.
The stromal compartments in pancreatic cancer: are there any therapeutic targets?
Cancer Lett. 2014; 343(2):147-55
Doi: 10.1016/j.canlet.2013.09.039
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant stromal response also known as a desmoplastic reaction. Pancreatic Stellate Cells have been identified as playing a key role in pancreatic cancer desmoplasia. There is accumulating evidence that the stroma contributes to tumour progression and to the low therapeutic response of PDAC patients. In this review we described the main actors of the desmoplastic reaction within PDAC and novel therapeutic approaches that are being tested to block the detrimental function of the stroma.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology, therapeutic use
- Cell Compartmentation - drug effects
- Drug Delivery Systems - administration & dosage
- Humans - administration & dosage
- Pancreatic Neoplasms - drug therapy
- Stromal Cells - drug effects
- Tumor Microenvironment - drug effects
- Find related publications in this database (Keywords)
- Tumour microenvironment
- Pancreatic cancer
- Stroma
- Pancreatic Stellate Cells