Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Lunardi, S; Lim, SY; Muschel, RJ; Brunner, TB.
IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
Oncoimmunology. 2015; 4(9):e1027473
Doi: 10.1080/2162402X.2015.1027473
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- Co-authors Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
- Find related publications in this database (Keywords)
- CXCL10
- IP-10
- pancreatic cancer
- pancreatic stellate cells
- regulatory T cells