Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Miles, KA; Lee, TY; Goh, V; Klotz, E; Cuenod, C; Bisdas, S; Groves, AM; Hayball, MP; Alonzi, R; Brunner, T, , Experimental, Cancer, Medicine, Centre, Imaging, Network, Group.
Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography.
Eur Radiol. 2012; 22(7):1430-41
Doi: 10.1007/s00330-012-2379-4
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- Co-authors Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- Dynamic contrast-enhanced computed tomography (DCE-CT) assesses the vascular support of tumours through analysis of temporal changes in attenuation in blood vessels and tissues during a rapid series of images acquired with intravenous administration of iodinated contrast material. Commercial software for DCE-CT analysis allows pixel-by-pixel calculation of a range of validated physiological parameters and depiction as parametric maps. Clinical studies support the use of DCE-CT parameters as surrogates for physiological and molecular processes underlying tumour angiogenesis. DCE-CT has been used to provide biomarkers of drug action in early phase trials for the treatment of a range of cancers. DCE-CT can be appended to current imaging assessments of tumour response with the benefits of wide availability and low cost. This paper sets out guidelines for the use of DCE-CT in assessing tumour vascular support that were developed using a Delphi process. Recommendations encompass CT system requirements and quality assurance, radiation dosimetry, patient preparation, administration of contrast material, CT acquisition parameters, terminology and units, data processing and reporting. DCE-CT has reached technical maturity for use in therapeutic trials in oncology. The development of these consensus guidelines may promote broader application of DCE-CT for the evaluation of tumour vascularity. Key Points • DCE-CT can robustly assess tumour vascular support • DCE-CT has reached technical maturity for use in therapeutic trials in oncology • This paper presents consensus guidelines for using DCE-CT in assessing tumour vascularity.
- Find related publications in this database (using NLM MeSH Indexing)
- Contrast Media - standards
- Forecasting - administration & dosage
- Humans - administration & dosage
- Neoplasms - blood supply, diagnostic imaging
- Neovascularization, Pathologic - diagnostic imaging
- Practice Guidelines as Topic - administration & dosage
- Reference Standards - administration & dosage
- Tomography, X-Ray Computed - standards, trends
- Find related publications in this database (Keywords)
- Tomography
- X-ray computed
- Contrast media
- Neoplasms
- Blood supply
- Diagnostic imaging
- Methods
- Standards
- Guideline