Medizinische Universität Graz - Research portal
Selected Publication:
Brunner, TB; Grabenbauer, GG; Klein, P; Baum, U; Papadopoulos, T; Bautz, W; Hohenberger, W; Sauer, R.
Phase I trial of strictly time-scheduled gemcitabine and cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer.
Int J Radiat Oncol Biol Phys. 2003; 55(1):144-53
Doi: 10.1016/s0360-3016(02)03818-x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Brunner Thomas Baptist
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- PURPOSE: Maximal therapeutic gain in xenograft sarcoma and toxicity for jejunal mucosa is time dependent for concurrent gemcitabine and radiotherapy (RT). We used a time-dependent schedule to determine the maximal-tolerated dose and dose-limiting toxicities (DLTs; Grade 4 hematologic or Grade 3 other toxicity). METHODS AND MATERIALS: Patients with pancreatic cancer (n = 33), periampullary carcinoma (n = 1), or bile duct cancer (n = 2) were treated with 3-day conformal RT with 50.4 Gy (tumor, lymphatics) plus a 5.4-Gy boost. Concurrent cisplatin (20 mg/m(2)/d on Days 1-5 and 29-33) and gemcitabine (initially 600 mg/m(2), weekly on Fridays 68 h before RT) were administered. Because of DLT, the doses were reduced to 500 mg/m(2) weekly and then 500, 400, or 300 mg/m(2) on Days 2, 5, 26, 33. RESULTS: DLT occurred at all dose levels of gemcitabine >300 mg/m(2). Fourteen patients were treated at the recommended Phase II dose of gemcitabine (300 mg/m(2)) without DLT. The response to chemoradiation allowed 10 of 30 initially unresectable patients with primary pancreatic carcinoma to undergo radical surgery, including a complete response in 2 cases. CONCLUSIONS: At the recommended Phase II dose, chemoradiation with gemcitabine and cisplatin can be administered safely in pancreatic carcinoma. However, at higher dose levels, toxicity is severe and frequent. Patients with a chance for conversion to resection could benefit from this schedule.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Antineoplastic Combined Chemotherapy Protocols - adverse effects, therapeutic use
- Blood Cells - drug effects, radiation effects
- Cisplatin - administration & dosage
- Combined Modality Therapy - administration & dosage
- Deoxycytidine - administration & dosage, analogs & derivatives
- Digestive System - drug effects
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Maximum Tolerated Dose - administration & dosage
- Middle Aged - administration & dosage
- Pancreatic Neoplasms - mortality, pathology, therapy
- Radiotherapy - adverse effects
- Radiotherapy Dosage - administration & dosage
- Find related publications in this database (Keywords)
- Phase I study
- chemoradiation
- pancreatic carcinoma
- gemcitabine