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Selected Publication:
Brunner, TB; Grabenbauer, GG; Kastl, S; Herrmann, O; Baum, U; Fietkau, R; Klein, P; Bautz, W; Schneider, T; Hohenberger, W; Sauer, R.
Preoperative Chemoradiation in Locally Advanced Pancreatic Carcinoma: A Phase II Study.
Onkologie. 2000; 23(5):436-442
Doi: 10.1159/000027214
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- BACKGROUND: Effectiveness and feasibility of preoperative chemoradiation (CRT) in locally advanced adenocarcinoma of the pancreas are evaluated. MATERIAL AND METHODS: 29 eligible of 37 registered patients were treated. 3d-Conformal external radiotherapy was delivered with a 1.8-Gy single dose and a total dose of 50.4 Gy plus 5.4 Gy boost. Simultaneous chemotherapy consisted of 5-fluorouracil and mitomycin C. RESULTS: Among 27 completely treated patients, 16 (59%) underwent surgery, 6 of them being irresectable intraoperatively. Ten patients (37%) had clear resection margins at Whipple's procedure. Eleven patients were not considered for surgery (7 still irresectable at restaging, 3 distant metastases, 1 refusal of surgery). Toxicity was predominantly hematological (grade 3: 30%, grade 4: 7%); furthermore, there was nausea/vomiting (grade 3: 20%, grade 4: 0%). No patient died perioperatively. The tumor-related overall survival rate was better for resected patients than for nonresected patients (50% vs. 6%, 2-year survival, p = 0.07), median overall survival was 9 months (median follow-up, 28 months). CONCLUSIONS: Neoadjuvant CRT without significant acute toxicity produced a resectability rate of 37% (all R0), which should be confirmed by randomized phase III studies. Copyright 2000 S. Karger GmbH, Freiburg
- Find related publications in this database (Keywords)
- pancreatic carcinoma
- radiotherapy
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- surgery