Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, DN; Hausen, A; Hengster, P; Reibnegger, GJ; Unterweger, B; Werner, ER; Hinterhuber, H; Dierich, MP; Wachter, H.
Is T-cell activation an unfavourable sign in i.v.-drug addicts infected with HIV?
Cancer Detect Prev. 1988; 12(1-6):277-282
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- In a longitudinal study, we examined 183 parenteral drug addicts who were imprisoned in Innsbruck, Austria, from March 1985 to March 1987. Thirty-seven percent of the patients had anti-HIV-antibodies. A 2-year follow-up of 43 seropositive patients revealed some evidence that urinary neopterin levels are of predictive value. Neopterin is produced from human macrophages upon stimulation with interferon gamma and, therefore, represents a sensitive parameter of activated T-cells. Eight patients who developed AIDS-related complex and one of them who contracted AIDS had significantly higher neopterin levels during the previous follow-up than the other groups of patients. Our data support the view that T-cell activation might be a crucial event in the induction of HIV reproduction in vivo.
- Find related publications in this database (using NLM MeSH Indexing)
- AIDS-Related Complex - immunology
- Acquired Immunodeficiency Syndrome - immunology
- Adolescent - immunology
- Adult - immunology
- Biopterin - analogs and derivatives
- HIV Antibodies - analysis
- Humans - analysis
- Longitudinal Studies - analysis
- Lymphocyte Activation - analysis
- Macrophages - analysis
- Neopterin - analysis
- Substance-Related Disorders - immunology
- T-Lymphocytes - immunology