Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Banekovich, M; Hausen, A; Hutterer, J; Reibnegger, G; Werner, ER; Gschnait, FD; Dierich, MP; Wachter, H.
Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1.
Clin Chem. 1988; 34(12):2415-2417
Doi: 10.1093/clinchem/34.12.2415
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- Reibnegger Gilbert
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- Abstract:
- We measured neopterin, a biochemical indicator for the activation of cell-mediated immune reactions, in urines from 105 individuals at risk of infection with human immunodeficiency virus-1 (HIV-1), 83 of whom were seropositive for antibody to HIV-1. We compared absolute numbers of T-cell subsets (CD4+ helper/inducer T-cells, CD8+ suppressor/cytotoxic T-cells), and the ratio of CD4+ T-cells to CD8+ T-cells with the urinary neopterin concentrations. Concentrations of neopterin in urine were inversely correlated with absolute numbers of CD4+ T-cells and with CD4+/CD8+ ratios in anti-HIV-1 seropositive subjects but not in those seronegative. Various statistical comparisons of the data further demonstrated that neopterin concentrations showed larger differences between anti-HIV-1 seronegative and seropositive subjects than absolute numbers of CD4+ T-cells or CD4+/CD8+ ratios. These results seem to indicate that neopterin concentrations increase earlier in the course of HIV-1 infection, before effects on T-cell subpopulations are detectable, and may further support the suggestion that neopterin measurement could be of use for monitoring infected subjects or predicting the progression of disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Adult - blood
- Antigens, Differentiation, T-Lymphocyte - analysis
- Biopterin - analogs and derivatives
- Female - analogs and derivatives
- HIV Seropositivity - analogs and derivatives
- Humans - analogs and derivatives
- Male - analogs and derivatives
- Middle Aged - analogs and derivatives
- Neopterin - analogs and derivatives
- T-Lymphocytes - cytology