Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Lehner, B; Omlor, G; Igrec, J; Brcic, I; Bergovec, M; Galsterer, S; Gilg, MM; Leithner, A.
Atypical cartilaginous tumors Diagnosis and therapy
ONKOLOGE. 2022;
Doi: 10.1007/s00761-022-01099-7
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Smolle Maria Anna
- Co-Autor*innen der Med Uni Graz
- Bergovec Marko
- Brcic Iva
- Gilg Magdalena Maria
- Igrec Jasminka
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- Abstract:
- Background Atypical cartilagineous tumours (ACTs) of short and long bones, previously termed as chondrosarcoma G1, are of locally aggressive behavior, but have little metastatic potential. Differentiation between ACTs and enchondromas is complex on clinical, radiological and histopathological basis. Objectives Epidemiology, diagnosis, and therapy of ACTs with specific focus on distinction from enchondroma. Materials and Methods Summary of international literature on ACTs and enchondromas. Results The incidence of enchondromas, and even more the one of ACTs, has increased over the years, indicating more frequent application of diagnostics. Contrary to enchondroma, ACTs may be associated with pain and present with radiological signs indicative of aggressive growth, such as deep endosteal scalloping. Performing biopsy only to differentiate between suspected enchondroma and ACT may be unhelpful as the acquired tissue specimen can lead to a "sampling error". Definite surgical therapy of ACTs of long and short bones has changed over the last years, shifting from radical tumour resection towards intralesional curettage. A primary watch-and-wait approach is possible in enchondroma using regular MRI check-ups. Conclusions Other than enchondroma, ACTs present with radiologic signs of aggressive growth. Nowadays, ACTs are preferably treated by intralesional curettage. Diagnosis, therapy and follow-up of cartilaginous tumours should be carried out at specialized tumour centers.
- Find related publications in this database (Keywords)
- Connective tissue neoplasms
- Enchondroma
- Chondrosarcoma
- Diaphyses
- Curettage