Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ginthör, NE; Artinger, K; Pollheimer, MJ; Stradner, MH; Eller, K.
Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab.
Clin Kidney J. 2022; 15(3): 564-566.
Doi: 10.1093/ckj/sfab250
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Ginthör Noemi
- Co-Autor*innen der Med Uni Graz
- Artinger Katharina
- Pollheimer Marion
- Stradner Martin Helmut
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- Abstract:
- Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
- Find related publications in this database (Keywords)
- B lymphocytes
- IgG4-related disease
- kidney disease
- membranous nephropathy