Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Hausen, A; Reibnegger, G; Werner, ER; Werner-Felmayer, G; Dierich, MP; Wachter, H.
Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.
J Acquir Immune Defic Syndr. 1989; 2(2):158-162
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Serum concentrations of interferon-gamma were measured in individuals seropositive for human immunodeficiency virus type 1 (HIV-1). According to the CDC classification system, 6 presented with stage IV-C, 5 with stage IV-A, 8 with stage III, and the remaining 24 individuals with stage II. A modified radioimmunoassay procedure for detection of interferon-gamma was used with a detection limit of 18 U/L. Approximately one-half (22/43) of the seropositives exhibited increased serum interferon-gamma concentrations compared with seronegative blood donors (n = 76). There was a significant association between serum interferon-gamma concentrations and CDC stages of the patients; patients classified as CDC IV-C had the highest concentrations. Further, a significant positive correlation was observed between serum interferon-gamma and serum neopterin concentrations in seropositive study participants. We conclude that interferon-gamma is present in increased concentrations in HIV-1 seropositives compared to seronegative blood donors. Diminished in vitro production of interferon-gamma by T-lymphocytes on stimulation with specific soluble antigens contrasts with increased levels of circulating interferon-gamma in patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Adult - blood
- Biopterin - analogs and derivatives
- Female - analogs and derivatives
- HIV-1 - analogs and derivatives
- Humans - analogs and derivatives
- Interferon Type II - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood