Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Chiodi, F; Albert, J; Asjö, B; Hagberg, L; Hausen, A; Norkrans, G; Reibnegger, G; Werner, ER; Wachter, H.
Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1.
AIDS. 1989; 3(5):285-288
Doi: 10.1097/00002030-198905000-00006
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Neopterin, a biochemical marker for the activation of cell-mediated immune reactions, was determined in serum and cerebrospinal fluid (CSF) from patients infected with HIV-1. A significant correlation was found between serum and CSF neopterin concentrations, although concentrations of neopterin in serum were more closely correlated with the clinical severity of HIV-1 infection than those in CSF. However, higher CSF levels were observed in patients with neurologic/psychiatric symptoms than in unaffected patients. Also, quotients of CSF neopterin versus serum neopterin concentrations were increased, indicating intrathecal production of neopterin. Positive HIV-1 isolation from peripheral blood mononuclear cells (PBMC) was associated with higher neopterin concentrations in serum, when compared with negative HIV-1 isolation. Neopterin in CSF appears to be a suitable biochemical marker in patients with HIV-1 infection for detecting overt neurologic/psychiatric disturbances. The data suggest that in HIV-1 infected patients, cell-mediated immune reactions might be activated intrathecally and might contribute to neuropsychiatric disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Adult - blood
- Aged - blood
- Biopterin - analogs and derivatives
- Dementia - blood
- Female - blood
- HIV-1 - blood
- Humans - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Nervous System Diseases - blood