Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reibnegger, G; Fuchs, D; Hausen, A; Werner, ER; Werner-Felmayer, G; Wachter, H.
Generalized likelihood ratio concept and logistic regression analysis for multiple diagnostic categories.
Clin Chem. 1989; 35(6):990-994
Doi: 10.1093/clinchem/35.6.990
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Albert (Clin Chem 1982;28:1113-9) has proposed estimation of likelihood ratios by logistic regression analysis. The usual likelihood-ratio approach for estimation of post-test probability of disease from sensitivity and specificity data of a diagnostic test has been extended by Birkett (J Clin Epidemiol 1988; 41:491-4) for situations with more than two diagnostic categories. We suggest here a combination of these ideas, demonstrating this by a re-evaluation of previously published data on the validity of neopterin as a tool for differential diagnosis between chronic non-A, non-B hepatitis and fatty liver. Analysis of neopterin data in combination with the ratio between serum concentrations of aspartate aminotransferase and of alanine aminotransferase yielded a good discrimination between three mutually exclusive diagnostic categories, namely, fatty liver and chronic persistent and chronic aggressive non-A, non-B hepatitis. The approach is flexibly applicable to situations with different pre-test probabilities. The sum of estimated post-test probabilities deviates slightly from the sum of pre-test probabilities. This deviation is a function of the coefficients obtained in logistic regression, and an analytical expression for the deviation is given. The generalized likelihood-ratio approach appears promising in complex diagnostic situations when multiple diagnostic tests are available.
- Find related publications in this database (using NLM MeSH Indexing)
- Alanine Transaminase - blood
- Aspartate Aminotransferases - blood
- Biopterin - analogs and derivatives
- Chronic Disease - analogs and derivatives
- Diagnosis, Differential - analogs and derivatives
- Fatty Liver - diagnosis
- Hepatitis C - diagnosis
- Humans - diagnosis
- Neopterin - diagnosis
- Regression Analysis - diagnosis