Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Werner, ER; Werner-Felmayer, G; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H.
Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.
Biochem J. 1989; 262(3):861-866
Doi: 10.1042/bj2620861
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- In all of eight tested human cells and cell lines with inducible indoleamine 2,3-dioxygenase (EC 1.13.11.17) tetrahydrobiopterin biosynthesis was activated by interferon-gamma. This was demonstrated by GTP cyclohydrolase I (EC 3.5.4.16) activities and intracellular neopterin and biopterin concentrations. Pteridine synthesis was influenced by extracellular tryptophan. In T 24-cell extracts, submillimolar concentrations of tetrahydrobiopterin stimulated the indoleamine 2,3-dioxygenase reaction.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopterin - analogs and derivatives
- Coenzymes - metabolism
- Enzyme Activation - drug effects
- Fibroblasts - metabolism
- GTP Cyclohydrolase - metabolism
- Humans - metabolism
- Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
- Interferon Type II - pharmacology
- Macrophages - metabolism
- Neopterin - metabolism
- Tryptophan - pharmacology
- Tryptophan Oxygenase - metabolism
- Tumor Cells, Cultured - metabolism