Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Werner-Felmayer, G; Werner, ER; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H.
Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells.
Biol Chem Hoppe Seyler. 1989; 370(9):1063-1069
Doi: 10.1515/bchm3.1989.370.2.1063
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- The capacity of recombinant interferon-alpha, -beta and -gamma, of bacterial lipopolysaccharide and of recombinant tumour necrosis factor-alpha to induce indoleamine 2,3-dioxygenase and synthesis of pteridines was studied in human peripheral blood mononuclear cells, human macrophages and normal dermal fibroblasts. The action of interferon-alpha and -beta on macrophages was supported by lymphocyte factors as indicated by the effect of these mediators in the absence or presence of lymphocytes. Tumour necrosis factor-alpha alone was ineffective in peripheral blood mononuclear cells and macrophages, but it significantly increased the action of all three interferon species on macrophages and fibroblasts. Lipopolysaccharide directly affected macrophages or dermal fibroblasts and enhanced the effect of interferon-gamma. However, in the presence of lymphocytes, the action of lipopolysaccharide was mediated via interferon-gamma.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopterin - analogs and derivatives
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- Humans - metabolism
- Interferon Type I - pharmacology
- Interferon Type I, Recombinant - pharmacology
- Interferon-gamma, Recombinant - pharmacology
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