Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reibnegger, G; Fuchs, D; Goedert, JJ; Hausen, A; Krämer, A; Werner, ER; Werner-Felmayer, G; Dierich, MP; Wachter, H.
Urinary neopterin concentrations and T-cell subset data in HIV-1 infection.
Klin Wochenschr. 1990; 68(1):43-48
Doi: 10.1007/BF01648890
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- Reibnegger Gilbert
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- Abstract:
- We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - immunology
- Adult - immunology
- Biopterin - analogs and derivatives
- CD4-Positive T-Lymphocytes - immunology
- Cohort Studies - immunology
- HIV Infections - diagnosis
- HIV Seropositivity - immunology
- HIV-1 - immunology
- Homosexuality - immunology
- Humans - immunology
- Male - immunology
- Neopterin - immunology
- T-Lymphocytes - immunology
- T-Lymphocytes, Regulatory - immunology