Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tauscher, PM; Gui, J; Shimmi, O.
Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints.
Development. 2016; 143(20): 3742-3750.
Doi: 10.1242/dev.130427
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Tauscher Petra
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- Abstract:
- The bone morphogenetic protein (BMP) signaling network, comprising evolutionary conserved BMP2/4/Decapentaplegic (Dpp) and Chordin/Short gastrulation (Sog), is widely utilized for dorsal-ventral (DV) patterning during animal development. A similar network is required for posterior crossvein (PCV) formation in the Drosophila pupal wing. Although both transcriptional and post-transcriptional regulation of co-factors in the network gives rise to tissue-specific and species-specific properties, their mechanisms are incompletely understood. In Drosophila, BMP5/6/7/8-type ligands, Screw (Scw) and Glass bottom boat (Gbb), form heterodimers with Dpp for DV patterning and PCV development, respectively. Sequence analysis indicates that the Scw ligand contains two N-glycosylation motifs: one being highly conserved between BMP2/4- and BMP5/6/7/8-type ligands, and the other being Scw ligand specific. Our data reveal that N-glycosylation of the Scw ligand boosts BMP signaling both in cell culture and in the embryo. In contrast, N-glycosylation modifications of Gbb or Scw ligands reduce the consistency of PCV development. These results suggest that tolerance for structural changes of BMP5/6/7/8-type ligands is dependent on developmental constraints. Furthermore, gain and loss of N-glycosylation motifs in conserved signaling molecules under evolutionary constraints appear to constitute flexible modules to adapt to developmental processes.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Bone Morphogenetic Proteins - genetics, metabolism
- Drosophila - administration & dosage
- Drosophila Proteins - genetics, metabolism
- Embryo, Nonmammalian - metabolism
- Gene Expression Regulation, Developmental - genetics, physiology
- Glycosylation - administration & dosage
- Mice, Transgenic - administration & dosage
- Signal Transduction - genetics, physiology
- Wings, Animal - embryology, metabolism
- Find related publications in this database (Keywords)
- Drosophila
- N-glycosylation
- Protein evolution
- Bone morphogenetic protein (BMP)
- Patterning
- Post-transcriptional regulation