Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bruckner, M; Neset, M; O'Reilly, M; Lee, TF; Cheung, PY; Schmölzer, GM.
Haemodynamic changes with varying chest compression rates in asphyxiated piglets.
Arch Dis Child Fetal Neonatal Ed. 2023; 108(2):200-203 Doi: 10.1136/archdischild-2021-323271
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Krainer Marlies; Schmölzer Georg
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Abstract:: BACKGROUND: Current neonatal resuscitation guidelines recommend that chest compressions (CCs) be delivered at a rate of 90/min. The aim of the study was to investigate the haemodynamic effects of different CC rates in a neonatal piglet model. METHODS: Six asphyxiated piglets were randomised to CC with rates of 60/min, 90/min, 120/min, 150/min and 180/min for 1 min at each rate. CCs superimposed with sustained inflations were performed with an automated CC machine. RESULTS: Six newborn piglets (age 0-3 days, weight 2.0-2.3 kg) were included in the study. Overall, there was a gradual increase in stroke volume, minimum and maximum rate of left ventricle pressure change (dp/dt_min and dp/dt_max), and carotid blood flow until CC rate of 150/min, with a level-off effect at a CC rate of 180/min. However, cardiac output continued to increase with the highest being at a CC rate of 180/min. CONCLUSION: Rate of CC was associated with changes in haemodynamic parameters during cardiopulmonary resuscitation. CC rate of 150-180/min during CC resulted in the highest cardiac output and arterial blood pressure. TRIAL REGISTRATION NUMBER: Preclincialtrials.eu PCTE0000249.
Find related publications in this database (using NLM MeSH Indexing): Animals - administration & dosage; Animals, Newborn - administration & dosage; Cardiopulmonary Resuscitation - methods; Heart Arrest - administration & dosage; Heart Massage - methods; Hemodynamics - physiology; Swine - administration & dosage
Find related publications in this database (Keywords): resuscitation; neonatology