Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Artner-Dworzak, E; Hausen, A; Reibnegger, G; Werner, ER; Werner-Felmayer, G; Dierich, MP; Wachter, H.
Urinary excretion of porphyrins is increased in patients with HIV-1 infection.
AIDS. 1990; 4(4):341-344
Doi: 10.1097/00002030-199004000-00009
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Urine concentrations of total porphyrins and of porphyrin precursors, delta-aminolaevulinic acid and porphobilinogen, were analysed in the first-morning urine samples of 36 people with established HIV-1 infection. For comparison, we also analysed the urine samples of 26 healthy HIV-seronegative people. In patients with HIV-1 infection concentrations of total porphyrins were found to be significantly higher than in healthy controls. Furthermore, there was a close correlation between concentrations of total porphyrins and porphobilinogen and urine neopterin concentrations in patients. Our data indicate an association between chronic immune activation and altered porphyrin metabolism. The data may provide a rationale for the observation of acute porphyria in patients with HIV-1 infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - classification
- Adolescent - classification
- Adult - classification
- Aminolevulinic Acid - immunology
- Biopterin - analogs and derivatives
- Female - analogs and derivatives
- HIV Seropositivity - classification
- Humans - classification
- Immunity, Cellular - classification
- Levulinic Acids - urine
- Male - urine
- Metabolic Clearance Rate - urine
- Middle Aged - urine
- Neopterin - urine
- Porphobilinogen - urine
- Porphyrins - immunology
- Substance Abuse, Intravenous - immunology