Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Möller, AA; Reibnegger, G; Stöckle, E; Werner, ER; Wachter, H.
Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.
J Acquir Immune Defic Syndr. 1990; 3(9):873-876
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- We investigated serum neopterin, tryptophan, and kynurenine concentrations in 23 HIV-1 seropositive patients (Walter Reed Stage 4-6). Ten patients presented with polyneuropathy and three with dementia, one of the patients with dementia also had polyneuropathy and dementia. We found significant associations between lower trytophan concentrations and neurologic/psychiatric symptoms. The negative correlation of tryptophan with kynurenine and neopterin concentrations indicates activity of indoleamine 2,3-dioxygenase (IDO) in patients. IDO can be induced by cytokines such as interferon-gamma and therefore low tryptophan levels may result from chronic immune stimulation in HIV-1 seropositives.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Adult - blood
- Biopterin - analogs and derivatives
- Dementia - etiology
- Humans - etiology
- Kynurenine - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Peripheral Nervous System Diseases - etiology
- Tryptophan - blood