Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Greinix, HT.
Metabolomics: a novel way to diagnose cGVHD?
BLOOD. 2021; 139(2): 161-162.
Doi: 10.1182/blood.2021014041
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- In this issue of Blood, Subburaj et al report on results from using metabolomics (the science of studying small molecules known as metabolites) to measure the metabolites in biofluids, cells, and tissues. They longitudinally followed 222 pediatric and adolescent patients from 27 international transplantation centers as part of the prospective Predictive Biomarkers for Pediatric Chronic Graft-Versus-Host Disease (ABLE-cGVHD) biomarker trial.1 Risk-assignment analysis of centrally stored and analyzed plasma samples on days +100 to 114 after allogeneic hematopoietic cell transplantation (HCT) and onset analysis at diag-nosis of chronic graft-versus-host disease (cGVHD) showed that plasma a-ketoglutaric acid was consistently elevated both before and at onset of cGVHD in multiregression analysis. Furthermore, metabolomic profiling allowed late acute GVHD (aGVHD) to be distinguished from cGVHD.