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SHR Neuro Cancer Cardio Lipid Metab Microb

Bonhenry, D; Schober, R; Schindl, R.
Twisting gating residues in the Orai pore Comment
CELL CALCIUM. 2021; 93: 102323 Doi: 10.1016/j.ceca.2020.102323
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Leading authors Med Uni Graz: Schindl Rainer
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Abstract:: The store-operated calcium channels Orai13 form extraordinary long and funnel like pores, in stark contrast to a classical pore loop architecture. A hydrophobic segment centrally located in the Orai pore controls gating. Here, we comment on a recent work that describes decisive binding between three residues that controls the open and closed conformation of Orai channels.
Find related publications in this database (Keywords): STIM1; Orai1; Pore; Gating; Ca2+ channel