Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bonhenry, D; Schober, R; Schindl, R.
Twisting gating residues in the Orai pore Comment
CELL CALCIUM. 2021; 93: 102323
Doi: 10.1016/j.ceca.2020.102323
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schindl Rainer
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- Abstract:
- The store-operated calcium channels Orai13 form extraordinary long and funnel like pores, in stark contrast to a classical pore loop architecture. A hydrophobic segment centrally located in the Orai pore controls gating. Here, we comment on a recent work that describes decisive binding between three residues that controls the open and closed conformation of Orai channels.
- Find related publications in this database (Keywords)
- STIM1
- Orai1
- Pore
- Gating
- Ca2+ channel