Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Müllegger, RR; Millner, MM; Stanek, G; Spork, KD.
Penicillin G sodium and ceftriaxone in the treatment of neuroborreliosis in children--a prospective study.
INFECTION. 1991; 19(4): 279-283.
Doi: 10.1007/BF01644967
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- Führende Autor*innen der Med Uni Graz
- Muellegger Robert
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- Abstract:
- A controlled clinical study was set up to examine whether penicillin G sodium (PG) or ceftriaxone (C) is superior in the treatment of acute neuroborreliosis in childhood. Within a time period of 18 months 77 children with symptoms indicative of Lyme borreliosis of the central nervous system (CNS) were seen. In 23 of these children Borrelia burgdorferi specific cerebrospinal fluid (CSF) parameters confirmed the diagnosis of a neuroborreliosis. These children were treated at random with intravenous (i.v.) PG 400,000-500,000 I.U./kg/day for 14 days (group I) or with i.v. ceftriaxone 75-93 mg/kg/day for 14 days (group II), respectively. Clinical examination and a set of diagnostic laboratory parameters were done at admission, right after therapy, three, six and partly 12 months after therapy. The general condition of all children in both groups improved dramatically during antibiotic therapy, and no relapse occurred within the observation period. Considering the clear and comparable decrease of B. burgdorferi serum titres and the clinical outcome (duration of disease and follow-up for at least six months) in children of both groups no difference between both antibiotic drugs can be demonstrated.
- Find related publications in this database (using NLM MeSH Indexing)
- Ceftriaxone - administration and dosage
- Central Nervous System Diseases - blood
- Child - blood
- Child, Preschool - blood
- Enzyme-Linked Immunosorbent Assay - blood
- Female - blood
- Follow-Up Studies - blood
- Humans - blood
- Infusions, Intravenous - blood
- Lyme Disease - blood
- Male - blood
- Penicillin G - administration and dosage
- Prospective Studies - administration and dosage
- Treatment Outcome - administration and dosage