Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Forsman, A; Hagberg, L; Larsson, M; Norkrans, G; Reibnegger, G; Werner, ER; Wachter, H.
Immune activation and decreased tryptophan in patients with HIV-1 infection.
J Interferon Res. 1990; 10(6):599-603
Doi: 10.1089/jir.1990.10.599
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- We compared tryptophan, neopterin, and interferon-gamma (IFN-gamma) concentrations in serum and cerebrospinal fluid (CSF) of 22 patients with human immunodeficiency virus type 1 (HIV-1) infection. Tryptophan levels were found to be decreased in CSF and serum of patients whereas neopterin levels in CSF and serum and serum IFN-gamma concentrations were increased compared to healthy HIV-1 seronegatives. Tryptophan concentrations correlated negatively to neopterin concentrations, and serum neopterin concentrations correlated positively to IFN-gamma concentrations. Thus, decrease of tryptophan levels is associated with chronic immune stimulation in patients with HIV-1 infection. From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- Enzyme Induction - analogs and derivatives
- HIV Infections - immunology
- HIV-1 - immunology
- Humans - immunology
- Interferon Type II - blood
- Middle Aged - blood
- Neopterin - blood
- Tryptophan - blood
- Tryptophan Oxygenase - biosynthesis