Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Krämer, A; Reibnegger, G; Werner, ER; Dierich, MP; Goedert, JJ; Wachter, H.
Neopterin and beta 2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection.
INFECTION. 1991; 19 Suppl 2(2): S98-102.
Doi: 10.1007/BF01644476
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- Reibnegger Gilbert
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- Abstract:
- The great majority of individuals with human immunodeficiency virus type 1 (HIV-1) infection presents with no signs or symptoms, or only lymphadenopathy. To initiate prophylactic measures in time it is necessary to establish risk criteria. CD4+ cell counts are significant predictors. Supplementary methods to improve the predictive information of CD4+ cell counts are still required. In addition, CD4+ cell counting is laborious, expensive, and restricted to specialized laboratories. Thus, there is also a place for more easily performed laboratory tests with similar predictive value as CD4+ cell counts. Neopterin and beta 2-microglobulin levels proved to be significant predictors of AIDS risk in HIV-1 seropositives. The predictive value of both parameters is equal to CD4+ cell counts and both markers are significant joint predictors in addition to CD4+ cell counts. Measurement of the parameters is done in serum (neopterin and beta 2-microglobulin) or urine (neopterin) specimens which reduces the risk of HIV-1 transmission compared to handling of whole-blood samples as it is required for cell counting. Although more studies are needed, especially in developing countries and in persons receiving zidovudine, it can be recommended to use neopterin and beta 2-microglobulin as additional marker to estimate AIDS risk in HIV-1 seropositive individuals. Moreover, both markers may be useful for this purpose without CD4+ cell counts if cell counting is not available.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - blood
- Biological Markers - blood
- Biopterin - analogs and derivatives
- CD4-Positive T-Lymphocytes - analogs and derivatives
- HIV-1 - analysis
- Humans - analysis
- Leukocyte Count - analysis
- Neopterin - analysis
- Predictive Value of Tests - analysis
- Prognosis - analysis
- beta 2-Microglobulin - analysis