Medizinische Universität Graz - Research portal
Selected Publication:
Fuchs, D; Reibnegger, G; Werner, ER; Vinazzer, H; Wachter, H.
Low haemoglobin in haemophilia children is associated with chronic immune activation.
Acta Haematol. 1991; 85(2):62-65
Doi: 10.1159/000204858
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- Co-authors Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Anaemia is a frequent complication in patients with human immunodeficiency virus type 1 (HIV-1) infection. We tested 14 children with severe haemophilia (9 HIV-1 antibody seropositive CDC stage IIA, 5 seronegative) for haemoglobin and urinary neopterin concentrations and found a negative correlation between neopterin and haemoglobin (rs = -0.745, p = 0.007; Spearman's rank correlation). This finding suggests that chronic immune activation, possibly along with the release of specific cytokines such as interferon gamma and tumor necrosis factor alpha may be involved in the pathogenesis of anaemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anemia - blood
- Biopterin - analogs and derivatives
- Child - analogs and derivatives
- HIV Seropositivity - analogs and derivatives
- Hemoglobins - metabolism
- Hemophilia A - complications
- Humans - complications
- Male - complications
- Neopterin - complications
- Find related publications in this database (Keywords)
- ANEMIA
- HIV-1 INFECTION
- IMMUNE STIMULATION
- NEOPTERIN