Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Möller, AA; Reibnegger, G; Werner, ER; Werner-Felmayer, G; Dierich, MP; Wachter, H.
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection.
Immunol Lett. 1991; 28(3):207-211
Doi: 10.1016/0165-2478(91)90005-U
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Reduced tryptophan and increased kynurenine concentrations have been reported in patients with human immunodeficiency virus type 1 (HIV-1) infection. From in vitro data it appears that activated indoleamine 2,3-dioxygenase (IDO) is involved in this metabolic change. IDO is inducible by interferon-(IFN)-gamma. We compared serum concentrations of IFN-gamma and neopterin (the biosynthesis of which is also inducible by IFN-gamma) with serum, tryptophan and kynurenine of 42 patients with HIV-1 infection. IFN-gamma, neopterin and kynurenine levels were significantly increased compared to HIV-1 seronegative controls whereas tryptophan was significantly decreased. Various significant correlations were found between tryptophan, kynurenine, IFN-gamma and neopterin concentrations. Highest degree of correlation was found between neopterin, IFN-gamma and the kynurenine per tryptophan quotient which is the ratio between the product and the substrate concentration of IDO. The data indicate that decreased tryptophan in HIV-1 seropositives may result from chronic immune activation and can be referred to increased activation of IDO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- Chromatography, High Pressure Liquid - analogs and derivatives
- Female - analogs and derivatives
- HIV Infections - blood
- HIV Seropositivity - blood
- HIV-1 - blood
- Humans - blood
- Interferon Type II - blood
- Kynurenine - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Radioimmunoassay - blood
- Tryptophan - blood
- Find related publications in this database (Keywords)
- HIV-1
- INDOLEAMINE 2
- -DIOXYGENASE
- INTERFERON-GAMMA
- NEOPTERIN
- TRYPTOPHAN