Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zangerle, R; Fuchs, D; Reibnegger, G; Fritsch, P; Wachter, H.
Markers for disease progression in intravenous drug users infected with HIV-1.
AIDS. 1991; 5(8):985-991
Doi: 10.1097/00002030-199108000-00010
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- We evaluated the number and percentage of CD4+ T cells, the ratio of CD4+ T cells to CD8+ T cells, the serum levels of beta 2- microglobulin and urinary levels of neopterin for their ability to predict disease progression (defined as clinical AIDS and/or oral candidiasis in combination with a CD4+ T cell count less than 400 x 10(6)/l). Thirty-eight intravenous drug users (IVDU) infected with HIV-1 without HIV-1-related symptoms were followed for a median observation period of 45 months. Cumulative incidence of disease progression was computed by the product-limit approach. The CD4+: CD8+ T-cell ratio (P = 0.001), the number (P = 0.002) and percentage (P = 0.05) of CD4+ T cells, and urinary neopterin (P = 0.007) were significant predictors for disease progression. Serum beta 2-microglobulin, which has been found to be of similar prognostic value as neopterin in homosexual men, did not show predictive power in this study of IVDU. The urinary neopterin concentrations obtained at entry of the study correlated with the values of the CD4+:CD8+ T-cell ratio and number and percentage of CD4+ T cells which were obtained at the end of the follow-up. These findings should help to identify, among HIV-1-infected IVDU, those at high risk of disease progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biological Markers -
- Biopterin - analogs and derivatives
- CD4-CD8 Ratio - analogs and derivatives
- CD4-Positive T-Lymphocytes - analogs and derivatives
- Female - analogs and derivatives
- HIV Infections - complications
- HIV-1 - complications
- Humans - complications
- Leukocyte Count - complications
- Male - complications
- Neopterin - complications
- Prognosis - complications
- Substance Abuse, Intravenous - complications
- Time Factors - complications
- beta 2-Microglobulin - metabolism
- Find related publications in this database (Keywords)
- HIV INFECTION
- INTRAVENOUS DRUG USERS
- IMMUNE ACTIVATION
- NEOPTERIN
- BETA-2-MICROGLOBULIN
- CD4+ T-CELLS