Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuith, LC; Fuchs, D; Hausen, A; Hetzel, H; Reibnegger, G; Werner, ER; Wachter, H.
Neopterin, a marker of cell-mediated immune activation in human pregnancy.
Int J Fertil. 1991; 36(6):372-375
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- High neopterin excretion is closely associated with activation of cell-mediated immunity. We studied urine and serum neopterin concentrations and serum interferon-gamma concentrations in normal pregnant women. In our study population, neopterin concentrations exceeded the normal range in 663 of 840 samples (79%). Neopterin levels increased with the time of pregnancy. Serum samples drawn from women in the third trimester of pregnancy also showed high neopterin concentrations in almost all cases; however, no circulating interferon-gamma was detected. Whereas neopterin is able to penetrate into the blood stream because of its small size (M = 253 D), diffusion of interferon-gamma is limited. Raised neopterin levels provide evidence for activated cell-mediated immunity during pregnancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- Female - analogs and derivatives
- Humans - analogs and derivatives
- Immunity, Cellular - analogs and derivatives
- Neopterin - analogs and derivatives
- Pregnancy - immunology
- Time Factors - immunology