Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Samsonov, M; Fuchs, D; Reibnegger, G; Belenkov, JN; Nassonov, EL; Wachter, H.
Patterns of serological markers for cellular immune activation in patients with dilated cardiomyopathy and chronic myocarditis.
Clin Chem. 1992; 38(5):678-680
Doi: 10.1093/clinchem/38.5.678
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- We determined serum concentrations of neopterin and beta 2-microglobulin, soluble markers of cellular immune activation, in 27 patients with either dilated cardiomyopathy (DCM) or chronic myocarditis. Neopterin and beta 2-microglobulin concentrations were respectively increased in 2 and 5 of 11 patients with DCM and in 11 and 9 of 16 patients with chronic myocarditis. A higher cardiac functional class (according to the New York Heart Association) was associated with greater neopterin and beta 2-microglobulin concentrations. During follow-up of patients, both neopterin and beta 2-microglobulin concentrations in serum correlated with the course of disease. Additionally, correlations were significant between left ventricular functional tests (end-diastolic volume, end-systolic volume, and ejection fraction) and neopterin and beta 2-microglobulin concentrations. We conclude that measurement of neopterin and beta 2-microglobulin are useful to monitor disease development in patients with myocardial inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- Cardiomyopathy, Dilated - immunology
- Chronic Disease - immunology
- Female - immunology
- Humans - immunology
- Immunity, Cellular - immunology
- Male - immunology
- Middle Aged - immunology
- Myocarditis - immunology
- Neopterin - immunology
- beta 2-Microglobulin - metabolism
- Find related publications in this database (Keywords)
- NEOPTERIN
- BETA-2-MICROGLOBULIN
- CONGESTIVE HEART FAILURE
- INFLAMMATION