Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zangerle, R; Reibnegger, G; Wachter, H; Fuchs, D.
Weight loss in HIV-1 infection is associated with immune activation.
AIDS. 1993; 7(2):175-181
Doi: 10.1097/00002030-199302000-00004
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: To assess the risk of developing weight loss, a decline in CD4+ T-cell count and AIDS-defining infections using urinary neopterin levels and CD4+ T-cell count. DESIGN: Retrospective record review. SETTING: A primary care clinic for patients at any stage of HIV infection at the University Hospital in Innsbruck, Austria, to which all patients with HIV-related diseases from the Austrian Tyrol are referred. PATIENTS, PARTICIPANTS: Seventy-nine out of the 311 HIV-seropositive individuals attending our clinic between July 1985 and December 1991 participated in the study. The selection was made after complete examination (clinical and laboratory) and follow-up of at least 6 months, up to 48 months (median, 28 months). Patients with severe diarrhoea were excluded. MAIN OUTCOME MEASURES: Correlation between body mass index, urinary neopterin and CD4+ T-cell count; development of AIDS-defining infections, weight loss, and a decline in CD4+ T-cells. Weight loss was recognized if > 10% of body weight, and there had been no concomitant AIDS-defining infection for at least 2 months. RESULTS: Initial urinary neopterin (P = 0.04), but not initial CD4+ T-cell count (P = 0.94), correlated with the body mass index obtained at the end of follow-up. Using the product-limit method, urinary neopterin predicted weight loss (P < 0.0001), decline in CD4+ T-cell count to < 200 x 10(6)/l (P = 0.006) and AIDS-defining infections (P = 0.009). CD4+ T-cell count was a better predictor of AIDS-defining infections (P < 0.0001) than of weight loss (P = 0.002). Results were confirmed by multivariate analysis. CONCLUSIONS: Weight loss > 10% of body weight is associated with immune activation.
- Find related publications in this database (using NLM MeSH Indexing)
- AIDS-Related Opportunistic Infections - blood
- Adolescent - blood
- Adult - blood
- Aged - blood
- Biopterin - analogs and derivatives
- Body Mass Index - analogs and derivatives
- CD4-Positive T-Lymphocytes - immunology
- Female - immunology
- HIV Infections - blood
- HIV-1 - blood
- Humans - blood
- Leukocyte Count - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Risk Factors - blood
- Weight Loss - immunology
- Find related publications in this database (Keywords)
- HIV
- WEIGHT LOSS
- AIDS-DEFINING INFECTIONS
- IMMUNE ACTIVATION
- NEOPTERIN
- CD4