Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Rauwolf, S; Bag, S; Rouqueiro, R; Schwaminger, SP; Dias-Cabral, AC; Berensmeier, S; Wenzel, W.
Insights on Alanine and Arginine Binding to Silica with Atomic Resolution.
J Phys Chem Lett. 2021; 12(38):9384-9390
Doi: 10.1021/acs.jpclett.1c02398
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schwaminger Sebastian
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- Abstract:
- Interactions of biomolecules with inorganic oxide surfaces such as silica in aqueous solutions are of profound interest in various research fields, including chemistry, biotechnology, and medicine. While there is a general understanding of the dominating electrostatic interactions, the binding mechanism is still not fully understood. Here, chromatographic zonal elution and flow microcalorimetry experiments were combined with molecular dynamic simulations to describe the interaction of different capped amino acids with the silica surface. We demonstrate that ion pairing is the dominant electrostatic interaction. Surprisingly, the interaction strength is more dependent on the repulsive carboxy group than on the attracting amino group. These findings are essential for conducting experimental and simulative studies on amino acids when transferring the results to biomolecule-surface interactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Alanine - chemistry, metabolism
- Arginine - chemistry, metabolism
- Calorimetry - administration & dosage
- Molecular Dynamics Simulation - administration & dosage
- Silicon Dioxide - chemistry, metabolism
- Static Electricity - administration & dosage
- Surface Properties - administration & dosage