Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Weiss, G; Fuchs, D; Hausen, A; Reibnegger, G; Werner, ER; Werner-Felmayer, G; Semenitz, E; Dierich, MP; Wachter, H.
Neopterin modulates toxicity mediated by reactive oxygen and chloride species.
FEBS Lett. 1993; 321(1):89-92
Doi: 10.1016/0014-5793(93)80627-7
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Neopterin, a pyrazino-pyrimidine derivative, is synthesized in excess by human monocytes/macrophages upon stimulation with interferon-gamma, a cytokine derived from activated I cells. Neopterin is furthermore produced constitutively. A relatively constant ratio between neopterin and its reduced form. 7,8-dihydroneopterin, has been described in human serum. In the study presented here we tested the ability of neopterin and its reduced form to modulate the effects of cytotoxic substances like hydrogen peroxide or hypochlorous acid and N-chloramine derivatives. We show that 7,8-dihydroneopterin potently reduces biological and chemical effects of these substances independently from the pH value. In contrast, at slightly alkaline pH (pH 7.5) neopterin enhances hydrogen peroxide and chloramine-T activity. This is demonstrated by increase of signal intensity in a luminol assay and also by enhancement of toxicity towards bacteria. Thus, the macrophage derived substance neopterin is able both to enhance and to reduce cytotoxicity in dependence of pH value and its oxidation state, and it may have a pivotal role in modulation of macrophage mediated effector mechanism.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biopterin - analogs and derivatives
- Blood Bactericidal Activity - analogs and derivatives
- Chemiluminescent Measurements - analogs and derivatives
- Chloramines - chemistry
- Escherichia coli - drug effects
- Humans - drug effects
- Hydrogen Peroxide - chemistry
- Hydrogen-Ion Concentration - chemistry
- Hypochlorous Acid - chemistry
- Macrophages - physiology
- Neopterin - physiology
- Pteridines - chemistry
- Find related publications in this database (Keywords)
- NEOPTERIN
- ANTIMICROBIAL TOXICITY
- MACROPHAGE
- HYDROGEN PEROXIDE
- CHLORAMINE