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Conforti, C; Corneli, P; Harwood, C; Zalaudek, I.
Evolving Role of Systemic Therapies in Non-melanoma Skin Cancer.
Clin Oncol (R Coll Radiol). 2019; 31(11): 759-768. Doi: 10.1016/j.clon.2019.08.011
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Zalaudek Iris
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Abstract:: Keratinocyte cancers - basal and cutaneous squamous cell carcinoma (BCC, cSCC) - are the most common forms of non-melanoma skin cancer (NMSC) and there has been a significant increase in their incidence globally in recent decades. Although the majority of BCC and cSCC are cured with conventional surgery or radiotherapy, certain tumour or patient-determined factors may result in these modalities being inadequate or inappropriate, for example, locally advanced or metastatic disease, high tumour multiplicity, patient comorbidities and patient preferences. In these clinical circumstances, systemic treatment may be indicated, and over the past 10 years a number of new systemic agents have been approved. Nonetheless, effective systemic therapy for keratinocyte cancers remains an area of significant unmet clinical need. Improved understanding of the molecular and immune pathogenesis underlying tumour growth and development is critical for driving future advances and is a research priority. The aim of this review is to provide clinicians with an overview of systemic treatments for BCC and cSCC and will focus on current evidence for conventional chemotherapy, targeted therapies, immunotherapy, adjuvant and neoadjuvant therapy, chemoprevention and future prospects for novel systemic treatment approaches.
Find related publications in this database (using NLM MeSH Indexing): Carcinoma, Squamous Cell - drug therapy, pathology; Humans - administration & dosage; Skin Neoplasms - drug therapy, pathology
Find related publications in this database (Keywords): Basal cell carcinoma; dermatofibrosarcoma; Merkel cell carcinoma; NMSC; oncology; squamous cell carcinoma; systemic therapies