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Selected Publication:
Marth, C; Weger, A; Müller-Holzner, E; Zeimet, AG; Moncayo-Naveda, H; Daxenbichler, G; Reibnegger, G; Fuchs, D; Wachter, H; Dapunt, O.
The prognostic value of nuclear roundness and neopterin in ovarian cancer.
Eur J Cancer. 1993; 29A(13):1863-1868
Doi: 10.1016/0959-8049(93)90539-R
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- Co-authors Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- The prognostic value of clinical factors, morphometric features and neopterin, a marker for macrophage activation, was investigated retrospectively in 68 ovarian carcinoma patients. Nuclear roundness was a good predictor of patient survival. About 50% of our patients showed neopterin concentrations above the cut-off level of 275 mumol/mol creatinine. Interestingly, those patients with elevated urinary neopterin concentration, and thus displaying a sign of activation of cell-mediated immunity, had a shorter survival than those with normal concentration. Applying a multivariate Cox regression analysis, the only independent parameters predicting patient survival were FIGO stage, residual disease, nuclear roundness and neopterin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopterin - analogs and derivatives
- Cell Nucleus - pathology
- Female - pathology
- Humans - pathology
- Immunity, Cellular - pathology
- Macrophage Activation - pathology
- Middle Aged - pathology
- Neopterin - pathology
- Ovarian Neoplasms - mortality
- Prognosis - mortality
- Retrospective Studies - mortality
- Survival Analysis - mortality