Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Murr, C; Fuchs, D; Gössler, W; Hausen, A; Reibnegger, G; Werner, ER; Werner-Felmayer, G; Esterbauer, H; Wachter, H.
Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes.
FEBS Lett. 1994; 338(2):223-226
Doi: 10.1016/0014-5793(94)80369-2
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- We have previously shown that neopterin, 6-D-erythro-trihydroxypropyl-pteridine, synthesized by human monocytes/macrophages upon stimulation by interferon-gamma, enhances toxicity of reactive oxygen at neutral or slightly alkaline pH (7.5), but not at acidic pH (below 6.5). In the present study, we explored in more detail the necessary requirements for neopterin to modulate the effects of hydrogen peroxide in a luminol-dependent chemiluminescence assay. We demonstrate that neopterin enhances hydrogen peroxide effects only in the presence of iron chelator complexes like iron-(III)- or iron-(II)-EDTA or iron-(III)-DTPA. Thus, iron chelator complexes together with neopterin may play an important role in macrophage-mediated effector mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopterin - analogs and derivatives
- Chemiluminescent Measurements - analogs and derivatives
- Edetic Acid - pharmacology
- Ferric Compounds - pharmacology
- Ferrous Compounds - pharmacology
- Hydrogen Peroxide - pharmacology
- Hydrogen-Ion Concentration - pharmacology
- Iron Chelating Agents - pharmacology
- Luminol - pharmacology
- Macrophages - physiology
- Neopterin - physiology
- Pentetic Acid - pharmacology
- Find related publications in this database (Keywords)
- NEOPTERIN
- MACROPHAGE
- HYDROGEN PEROXIDE
- IRON
- CHELATOR