Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Marth, C; Weiss, G; Koza, A; Reibnegger, G; Daxenbichler, G; Zeimet, AG; Fuchs, D; Wachter, H; Dapunt, O.
Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients.
Int J Cancer. 1994; 58(1):20-23
Doi: 10.1002/ijc.2910580105
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have recently been introduced in the treatment of chemotherapy-induced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM-CSF--to a greater extent than G-CSF--also induced neopterin, a sensitive marker of macrophages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon-gamma-mediated pathways in THP-I human myelomonocytic cells. The results suggest activation of immune effector cells by GM-CSF.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopterin - analogs and derivatives
- Cell Line - analogs and derivatives
- Female - analogs and derivatives
- Genital Neoplasms, Female - drug therapy
- Granulocyte Colony-Stimulating Factor - therapeutic use
- Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use
- Humans - therapeutic use
- Immunity, Cellular - drug effects
- Leukocyte Count - drug effects
- Middle Aged - drug effects
- Neopterin - drug effects
- Tumor Markers, Biological - biosynthesis