Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Baier-Bitterlich, G; Fuchs, D; Murr, C; Reibnegger, G; Werner-Felmayer, G; Sgonc, R; Böck, G; Dierich, MP; Wachter, H.
Effect of neopterin and 7,8-dihydroneopterin on tumor necrosis factor-alpha induced programmed cell death.
FEBS Lett. 1995; 364(2):234-238
Doi: 10.1016/0014-5793(95)00403-V
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Tumor necrosis factor-alpha and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8-dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin-derivatives on TNF alpha induced apoptosis of the monocyte-like cell line U937. At an elevated concentration 7,8-dihydroneopterin was found to superinduce TNF alpha mediated programmed cell death due to the formation of reactive oxygen intermediates. Our results imply that in combination with TNF alpha high concentrations of 7,8-dihydroneopterin enhances apoptosis due to oxidative stress on cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcysteine - pharmacology
- Animals - pharmacology
- Apoptosis - drug effects
- Biopterin - administration and dosage
- Cell Line - administration and dosage
- Drug Synergism - administration and dosage
- Hydrogen Peroxide - metabolism
- Neopterin - metabolism
- Oxidative Stress - drug effects
- Pteridines - administration and dosage
- Reactive Oxygen Species - metabolism
- Superoxide Dismutase - pharmacology
- Tumor Necrosis Factor-alpha - administration and dosage
- Find related publications in this database (Keywords)
- PTERIDINE
- APOPTOSIS
- REACTIVE OXYGEN INTERMEDIATE
- NEOPTERIN
- 7
- -DIHYDRONEOPTERIN
- HUMAN MONOCYTE