Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gieseg, SP; Reibnegger, G; Wachter, H; Esterbauer, H.
7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant.
FREE RADICAL RES. 1995; 23(2): 123-136.
Doi: 10.3109/10715769509064027
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo. The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/macrophage activation. We have found that in vitro 7,8-dihydroneopterin dramatically increases, in a dose dependent manner, the lag time of low density lipoprotein oxidation mediated by Cu++ ions or the peroxyl radical generator 2,2'-azobis (2-amidino propane) dihydrochloride (AAPH). 7,8-Dihydroneopterin also inhibits AAPH mediated oxidation of linoleate. The kinetic of the inhibition suggests that 7,8-dihydroneopterin is a potent chain breaking antioxidant which functions by scavenging lipid peroxyl radicals. No anti-oxidant activity was observed in any of the oxidation systems studied with the related compounds neopterin and pterin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amidines - pharmacology
- Antioxidants - pharmacology
- Biopterin - analogs and derivatives
- Copper - metabolism
- Dose-Response Relationship, Drug - metabolism
- Female - metabolism
- Humans - metabolism
- Linoleic Acid - metabolism
- Linoleic Acids - metabolism
- Lipoproteins, LDL - chemistry
- Macrophages - secretion
- Male - secretion
- Neopterin - secretion
- Oxidation-Reduction - secretion
- Pteridines - metabolism
- Pterins - pharmacology
- Vitamin E - antagonists and inhibitors
- Find related publications in this database (Keywords)
- NEOPTERIN
- 7
- DIHYDRONEOPTERIN
- LOW-DENSITY LIPOPROTEIN
- COPPER OXIDATION
- ANTIOXIDANT
- PEROXYL RADICAL