Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pritišanac, I; Zarin, T; Forman-Kay, JD; Moses, AM.
Whence Blobs? Phylogenetics of functional protein condensates.
Biochem Soc Trans. 2020; 48(5):2151-2158
Doi: 10.1042/BST20200355
Web of Science
PubMed
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- Pritisanac Iva
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- Abstract:
- What do we know about the molecular evolution of functional protein condensation? The capacity of proteins to form biomolecular condensates (compact, protein-rich states, not bound by membranes, but still separated from the rest of the contents of the cell) appears in many cases to be bestowed by weak, transient interactions within one or between proteins. Natural selection is expected to remove or fix amino acid changes, insertions or deletions that preserve and change this condensation capacity when doing so is beneficial to the cell. A few recent studies have begun to explore this frontier of phylogenetics at the intersection of biophysics and cell biology.
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