Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Niehaus, A; Shi, J; Grzenkowski, M; Diers-Fenger, M; Archelos, J; Hartung, HP; Toyka, K; Brück, W; Trotter, J.
Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination.
Ann Neurol. 2000; 48(3):362-371
Doi: 10.1002%2F1531-8249%28200009%2948%3A3%3C362%3A%3AAID-ANA11%3E3.0.CO%3B2-6
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- In multiple sclerosis (MS), remyelination of demyelinated lesions diminishes with disease progression for unknown reasons. Oligodendrocyte progenitor cells contribute to remyelination; however, antibodies specific for oligodendrocyte progenitor antigens could block remyelination by eliminating or impeding these cells. In myelinating cultures, cell lysis with antibody recognizing a progenitor cell-specific surface glycoprotein (AN2) suppressed the synthesis of myelin proteins. Cerebrospinal fluid from patients with relapsing-remitting active MS contains antibodies against AN2, whereas cerebrospinal fluid from patients with nonactive disease does not. This is the first report describing antibodies in MS against a progenitor cell-specific antigen that may contribute to the development and progression of chronically demyelinated lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Animals -
- Antibodies - immunology
- Blotting, Western - immunology
- Brain - metabolism
- Fluorescent Antibody Technique - metabolism
- Humans - metabolism
- Mice - metabolism
- Multiple Sclerosis, Relapsing-Remitting - immunology
- Myelin Sheath - immunology
- Nerve Fibers, Myelinated - immunology
- Neurons - immunology
- Oligodendroglia - immunology