Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Foessl, I; Bassett, JHD; Bjørnerem, Å; Busse, B; Calado, Â; Chavassieux, P; Christou, M; Douni, E; Fiedler, IAK; Fonseca, JE; Hassler, E; Högler, W; Kague, E; Karasik, D; Khashayar, P; Langdahl, BL; Leitch, VD; Lopes, P; Markozannes, G; McGuigan, FEA; Medina-Gomez, C; Ntzani, E; Oei, L; Ohlsson, C; Szulc, P; Tobias, JH; Trajanoska, K; Tuzun, Ş; Valjevac, A; van, Rietbergen, B; Williams, GR; Zekic, T; Rivadeneira, F; Obermayer-Pietsch, B.
Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").
FRONT ENDOCRINOL. 2021; 12: 720728
Doi: 10.3389/fendo.2021.720728
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- Führende Autor*innen der Med Uni Graz
- Fößl Ines
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Hassler Eva Maria
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- Abstract:
- A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals - including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing -omics data in order to advance musculoskeletal research and move towards "personalised medicine".
- Find related publications in this database (Keywords)
- bone and skeletal diseases
- phenotyping
- imaging
- animal models
- GEMSTONE
- COST